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We want to address this question by integrating different genomic data -from RNA-seq, to ATAC-seq and single-cell genomics- with functional experiments using our two animal model systems: zebrafish and turquoise killifish. Killifish form the vertebrate animal group with the shortest known lifespan, making it a perfect model for aging and derived diseases studies.\u00a0<\/span><\/p>\n![\"\"](\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\")
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Five relevant publications\u00a0<\/h2>\n
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\n- Marl\u00e9taz F*, Firbas PN*, Maeso I*, Tena JJ*, Bogdanovic O*, Perry M*, Wyatt CDR, de la Calle-Mustienes E, Bertrand S, Burguera D, Acemel RD, van Heeringen SJ, Naranjo S, Herrera-Ubeda C, Skvortsova K, Jimenez-Gancedo S, Aldea D, Marquez Y, Buono L, Kozmikova I, Permanyer J, Louis A, Albuixech-Crespo B, Le Petillon Y, Leon A, Subirana L, Balwierz PJ, Duckett PE, Farahani E, Aury JM, Mangenot S, Wincker P, Albalat R, Benito-Guti\u00e9rrez \u00c8, Ca\u00f1estro C, Castro F, D’Aniello S, Ferrier DEK, Huang S, Laudet V, Marais GAB, Pontarotti P, Schubert M, Seitz H, Somorjai I, Takahashi T, Mirabeau O, Xu A, Yu JK, Carninci P, Martinez-Morales JR, Crollius HR, Kozmik Z, Weirauch MT, Garcia-Fern\u00e0ndez J, Lister R, Lenhard B, Holland PWH, Escriva H, G\u00f3mez-Skarmeta JL, Irimia M. (2018) Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature 564:64-70.<\/li>\n
- Acemel RD*, Tena JJ*, Irastorza-Azcarate I*, Marl\u00e9taz F*, G\u00f3mez-Mar\u00edn C, de la Calle-Mustienes E, Bertrand S, Diaz SG, Aldea D, Aury JM, Mangenot S, Holland PW, Devos DP, Maeso I, Escriv\u00e1 H, G\u00f3mez-Skarmeta JL. (2016) A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation. Nat Genet. 48:336-341.<\/li>\n
- Smemo S*, Tena JJ*, Kim KH*, Gamazon ER, Sakabe NJ, G\u00f3mez-Mar\u00edn C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, N\u00f3brega MA. (2014 )Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 507:371-375.<\/li>\n
- Tena JJ*, Gonz\u00e1lez-Aguilera C*, Fern\u00e1ndez-Mi\u00f1\u00e1n A, V\u00e1zquez-Mar\u00edn J, Parra-Acero H, Cross JW, Rigby PW, Carvajal JJ, Wittbrodt J, G\u00f3mez-Skarmeta JL, Mart\u00ednez-Morales JR. (2014) Comparative epigenomics in distantly related teleost species identifies conserved cis-regulatory nodes active during the vertebrate phylotypic period. Genome Res. 24:1075-1085.<\/li>\n
- Tena JJ, Alonso ME, de la Calle-Mustienes E, Splinter E, de Laat W, Manzanares M, G\u00f3mez-Skarmeta JL. (2011) An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation. Nat Commun. 2:310.<\/li>\n<\/ul>\n
* Equal contribution<\/p>\n
Publicaciones completas<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.27.6″ _module_preset=”d057b755-ffa8-4fcd-923c-c94b7c9a9123″ global_colors_info=”{%22gcid-primary-color%22:%91%22color%22%93}”][\/et_pb_divider][et_pb_text _builder_version=”4.27.6″ _module_preset=”dc6ab383-11a3-454b-8ba1-6554be6042b4″ vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”0″ text_text_shadow_horizontal_length_tablet=”0px” text_text_shadow_vertical_length_tablet=”0px” text_text_shadow_blur_strength_tablet=”1px” link_text_shadow_horizontal_length_tablet=”0px” link_text_shadow_vertical_length_tablet=”0px” link_text_shadow_blur_strength_tablet=”1px” ul_text_shadow_horizontal_length_tablet=”0px” ul_text_shadow_vertical_length_tablet=”0px” ul_text_shadow_blur_strength_tablet=”1px” ol_text_shadow_horizontal_length_tablet=”0px” ol_text_shadow_vertical_length_tablet=”0px” ol_text_shadow_blur_strength_tablet=”1px” quote_text_shadow_horizontal_length_tablet=”0px” quote_text_shadow_vertical_length_tablet=”0px” quote_text_shadow_blur_strength_tablet=”1px” header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength_tablet=”1px” header_2_text_shadow_horizontal_length_tablet=”0px” header_2_text_shadow_vertical_length_tablet=”0px” header_2_text_shadow_blur_strength_tablet=”1px” header_3_text_shadow_horizontal_length_tablet=”0px” header_3_text_shadow_vertical_length_tablet=”0px” header_3_text_shadow_blur_strength_tablet=”1px” header_4_text_shadow_horizontal_length_tablet=”0px” header_4_text_shadow_vertical_length_tablet=”0px” header_4_text_shadow_blur_strength_tablet=”1px” header_5_text_shadow_horizontal_length_tablet=”0px” header_5_text_shadow_vertical_length_tablet=”0px” header_5_text_shadow_blur_strength_tablet=”1px” header_6_text_shadow_horizontal_length_tablet=”0px” header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}”]<\/p>\n
Lab members & Collaborators<\/h2>\n
\n<\/h3>\nLab members<\/h3>\nPhD Students<\/h4>\n
Lourdes Fuentes Gallardo
Marta Moreno O\u00f1ate
Alejandro Gil Galvez
Ana Burgos
Soraya Kalayanamontri<\/p>\n
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Post doctoral Associates<\/h4>\n
Silvia Naranjo Duran
Jose Maria Santos Pereira
Martin Franke
Christina Paliou
Pedro Manuel Martinez Garcia<\/p>\n
Technicians<\/h4>\n
Elisa de la Calle Mustienes
Valle Hernandez Perez<\/p>\n
Collaborators<\/h3>\n
Miguel Manzanares
Fernando Giraldez
Jaime Carvajal
Ozren Bogdanovich
Ignacio Maeso
Juan R. Mart\u00ednez-Morales
Manuel Irimia
Javier Lopez-Rios<\/p>\n
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Genome DynamicsEpigenomics in disease and aging Dr Juan J. Tena \u00a0Principal InvestigatorSummary\u00a0 As the average age of our society gradually increases, aging and related diseases have become key topics in […]<\/p>\n","protected":false},"author":3037,"featured_media":0,"parent":21588,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-20392","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20392","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/users\/3037"}],"replies":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/comments?post=20392"}],"version-history":[{"count":11,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20392\/revisions"}],"predecessor-version":[{"id":24306,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20392\/revisions\/24306"}],"up":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/21588"}],"wp:attachment":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/media?parent=20392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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