{"id":20739,"date":"2026-04-13T09:16:23","date_gmt":"2026-04-13T08:16:23","guid":{"rendered":"https:\/\/cabd.es\/dr-carlos-santos-ocana\/"},"modified":"2026-05-25T08:23:54","modified_gmt":"2026-05-25T07:23:54","slug":"dr-carlos-santos-ocana","status":"publish","type":"page","link":"https:\/\/cabd.es\/en\/investigation\/departments\/organismal-dynamics\/dr-carlos-santos-ocana\/","title":{"rendered":"Dr Carlos Santos Oca\u00f1a"},"content":{"rendered":"

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Organismal Dynamics<\/p>\n

Coenzyme Q synthesis in Saccharomyces cerevisae and its implication in the mitochondrial health. lifespan and ageing<\/a><\/h1>\n

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Dr Carlos Santos Oca\u00f1a<\/h4>\n

\u00a0Principal Investigator<\/p>\n

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Summary\u00a0<\/h2>\n
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\u00a0In progress…<\/p>\n

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Most relevant publications\u00a0<\/h2>\n
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  1. Doimo, M., Trevisson, E., Airik, R., Bergdoll, M.,\u00a0Santos-Oca\u00f1a,\u00a0C.<\/strong>, Hildebrandt, F., Navas, P., Pierrel, F., and Salviati, L. (2014). Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Biochim. Biophys. Acta\u00a01842, 1\u20136.<\/li>\n
  2. Gonz\u00e1lez-Mariscal, I., Garc\u00eda-Test\u00f3n, E., Padilla, S., Mart\u00edn-Montalvo, A., Pomares-Viciana, T., Vazquez-Fonseca, L., Gandolfo-Dom\u00ednguez, P., and\u00a0Santos-Oca\u00f1a, C.<\/strong>\u00a0(2014). Regulation of coenzyme Q biosynthesis in yeast: A new complex in the block. IUBMB Life n\/a\u2013n\/a.<\/li>\n
  3. Heeringa, S.F., Chernin, G., Chaki, M., Zhou, W., Sloan, A.J., Ji, Z., Xie, L.X., Salviati, L., Hurd, T.W.,\u00a0Santos Oca\u00f1a, C.<\/strong>, Vega-Warner, V., et al. (2011). COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest\u00a0121, 2013\u20132024.<\/li>\n
  4. Jimenez-Hidalgo, M.,\u00a0Santos-Oca\u00f1a, C.<\/strong>, Padilla, S., Villalba, J.M., L\u00f3pez-Lluch, G., Mart\u00edn-Montalvo, A., Minor, R.K., Sinclair, D.A., de Cabo, R., Navas, P., et al. (2009). NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell\u00a08, 140\u2013151.<\/li>\n
  5. Martin-Montalvo, A., Gonzalez-Mariscal, I., Padilla, S., Ballesteros, M., Brautigan, D.L., Navas, P.P., and\u00a0Santos-Ocana, C.<\/strong>\u00a0(2011). Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p\/Coq7p. Biochem. J.\u00a0114, 107\u2013114.<\/li>\n
  6. Martin-Montalvo, A., Gonzalez-Mariscal, I., Pomares-Viciana, T., Padilla-Lopez, S., Ballesteros, M., Vazquez-Fonseca, L., Gandolfo, P., Brautigan, D.L., Navas, P.,\u00a0Santos-Ocana, C.<\/strong>\u00a0\u00a0(2013). The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast. J. Biol. Chem.\u00a0288, 28126\u201328137.<\/li>\n
  7. Padilla, S., Tran, U.C., Jim\u00e9nez-Hidalgo, M., L\u00f3pez-Mart\u00edn, J.M., Mart\u00edn-Montalvo, a, Clarke, C.F., Navas, P., and\u00a0Santos-Oca\u00f1a, C.<\/strong>\u00a0(2009). Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cell. Mol. Life Sci.\u00a066, 173\u2013186.<\/li>\n
  8. Padilla-L\u00f3pez, S., Jim\u00e9nez-Hidalgo, M., Mart\u00edn-Montalvo, A., Clarke, C.F., Navas, P., and\u00a0Santos-Oca\u00f1a, C.<\/strong>, \u00a0(2009). Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochim. Biophys. Acta\u00a01788, 1238\u20131248.<\/li>\n
  9. Salviati, L., Trevisson, E., Rodriguez Hernandez, M.A., Casarin, A., Pertegato, V., Doimo, M., Cassina, M., Agosto, C., Desbats, M.A., Sartori, G.,\u00a0Santos-Oca\u00f1a, C.<\/strong>, et al. (2012). Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. J. Med. Genet.\u00a049, 187\u2013191.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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    Lab members & collaborators<\/h2>\n
    \n

    \u00a0<\/h3>\n

    Lab member<\/h3>\n

    Head of the goup<\/h4>\n

    Dr Carlos Santos Oca\u00f1a, +34 954 349 093, csanoca@upo.es <\/a>\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0orcid.org\/0000-0002-2379-796X<\/a><\/p>\n

    PhD Students<\/h4>\n

    Elena Garc\u00eda-Test\u00f3n P\u00e1ez<\/p>\n

    Collaborators<\/h3>\n

    Dr. Rafael Carlos de Cabo Moreno (NIA-NIH Baltimore)
    Dr. David Brautigan (University of Virginia, Charlottesville)
    Dr. Catherine F. Clarke (University of California Los Angeles)
    Dr. Jos\u00e9 Manuel Villalba Montoro (Universidad de C\u00f3rdoba)
    Dr. Leonardo Salviati (Universit\u00e0 di Padova)
    Dr. Sergio Padilla L\u00f3pez (Sanford Health Research Center, Sioux Falls, SD)
    Dr. Rafael Artuch (Hospital San Joan de Deu, Barcelona)
    Dra. Sandra Jackson (Tech University Hosp\u00ectal, Dresden)<\/p>\n

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    Organismal Dynamics Coenzyme Q synthesis in Saccharomyces cerevisae and its implication in the mitochondrial health. lifespan and ageing Dr Carlos Santos Oca\u00f1a \u00a0Principal Investigator Summary\u00a0 \u00a0In progress…     Most […]<\/p>\n","protected":false},"author":3010,"featured_media":0,"parent":20102,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-20739","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/users\/3010"}],"replies":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/comments?post=20739"}],"version-history":[{"count":18,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20739\/revisions"}],"predecessor-version":[{"id":24573,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20739\/revisions\/24573"}],"up":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20102"}],"wp:attachment":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/media?parent=20739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}