{"id":20888,"date":"2026-04-14T07:52:55","date_gmt":"2026-04-14T06:52:55","guid":{"rendered":"https:\/\/cabd.es\/investigation\/departments\/cell-biology-and-biotechnology\/dr-amando-flores\/"},"modified":"2026-11-03T11:49:52","modified_gmt":"2026-11-03T10:49:52","slug":"dr-amando-flores","status":"publish","type":"page","link":"https:\/\/cabd.es\/en\/investigation\/departments\/multicelular-dynamics\/dr-amando-flores\/","title":{"rendered":"Dr Amando Flores"},"content":{"rendered":"

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Multicellular Dynamics<\/p>\n

Evolution of drug-degrading and antibiotic-resistant bacterial consortia and strains<\/h1>\n

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Dr Amando Flores<\/h4>\n

Researcher<\/p>\n

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Summary<\/h2>\n
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Salmonella enterica<\/em>\u00a0serovar Tiphimurium is probably the best-characterised pathogenic bacteria. Previous studies have demonstrated that attenuated\u00a0Salmonella\u00a0<\/em>spp. specifically target and colonize solid tumors, which makes\u00a0Salmonella\u00a0<\/em>a particularly suitable vector for targeted drug delivery to cancer cells. In spite of the extensive variety of existing gene expression systems used in enteric bacteria, no appropriate control circuits are available for regulated expression in\u00a0Salmonella\u00a0<\/em>once it resides within infected cells. Our research group and Biomedal SL have developed bacterial regulatory circuits inducible by salicylate or by aspirin which induce the production of proteins when\u00a0Salmonella\u00a0<\/em>is inside the eukaryotic cell.<\/p>\n

Our group aims at assembling attenuated\u00a0Salmonella\u00a0<\/em>strains bearing this regulatory circuit able to produce and secrete different therapeutical agents with application in two biomedical topics. In one hand, we are constructing attenuated strains producing citotoxic agents and necrosis or apoptosis inducers, for their use in antitumor therapy. On the other hand, we are interested in obtaining strains producing eukaryotic transcription factors to be used as stem cells development inducers, strategy that constitutes a novel experimental approach in regenerative medicine.<\/p>\n<\/div>\n<\/div>\n

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Five relevant publications<\/h2>\n
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  • Saati-Santamar\u00eda, Z. Navarro-G\u00f3mez. P, Mart\u00ednez-Mancebo, JA, Ju\u00e1rez-Mugarza, M,\u00a0Flores, A<\/b>* and Canosa, I*. (2025). Genetic and species rearrangements in microbial consortia impact biodegradation potential.\u00a0ISME J.<\/i>\u00a0<\/b>doi: 10.1093\/ismejo\/wraf014.<\/i><\/li>\n
  • P. Prieto-Laria, A. Jim\u00e9nez-Rodr\u00edguez, A. R. Ruiz-Salvador, I. Canosa,\u00a0A. Flores<\/b>, Y. Colle, K. Borrego, N. O. Nu\u00f1ez, E. Alonso, P. Fern\u00e1ndez-Ib\u00e1\u00f1ez, T. Farias, M. Ballesteros.\u00a0<\/b>(<\/b>2025) From the lab to the river: Bimetallic clinoptilolite photocatalyst for antibiotic-resistant bacteria and emerging contaminants removal. J of Environl Chem Engineer<\/b>\u00a0doi: 10.1016\/j.jece.2025.116663<\/li>\n
  • Aulestia, M.,\u00a0Flores, A.<\/b>, Acosta-Jurado, S., Santero, E., and Camacho, E.M*. (2022) Genetic Characterization of the Ibuprofen-Degradative Pathway of\u00a0Rhizorhabdus wittichii<\/i>\u00a0MPO218.\u00a0Appl Environ Microbiol<\/b>\u00a088. 10.1128\/aem.00388-22.<\/li>\n
  • \u00c1lvarez-Mar\u00edn, M.T., Zarzuela, L., Camacho, E.M., Santero, E., and\u00a0Flores, A*<\/sup><\/b>. (2022) Detection by metagenomic functional analysis and improvement by experimental evolution of \u03b2-lactams resistance genes present in oil contaminated soils.\u00a0Sci Rep<\/i><\/b>\u00a012<\/b>: 10059.<\/li>\n
  • Aulestia, M.,\u00a0Flores, A.<\/b>, Mangas, E.L., P\u00e9rez-Pulido, A.J., Santero, E., and Camacho, E.M.* (2021) Isolation and genomic characterization of the ibuprofen-degrading bacterium\u00a0Sphingomonas<\/i>\u00a0strain MPO218.\u00a0Environ Microbiol<\/b>\u00a023<\/b>: 267\u2013280.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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    Lab members & Collaborators<\/h2>\n
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    Lab members<\/h3>\n

    Group leader:<\/h4>\n

    Dr Amando Flores, +34 954348917<\/p>\n

    Postdoctoral:<\/h4>\n

    Dr. Eva Camacho, +34 954348644
    Dr. Carlos Medina, +34 954348644
    Dr. Beatriz Mesa, +34 954348917<\/p>\n

    Collaborators<\/h3>\n

    Dr. Carlos Guzman (Helmholtz Centre for Infection Research, Braunschwig, Germany)
    Dr. Angel Cebolla (Biomedal SL, Sevilla)<\/p>\n

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    Multicellular Dynamics Evolution of drug-degrading and antibiotic-resistant bacterial consortia and strains Dr Amando Flores Researcher Summary   Salmonella enterica\u00a0serovar Tiphimurium is probably the best-characterised pathogenic bacteria. Previous studies have demonstrated […]<\/p>\n","protected":false},"author":3022,"featured_media":0,"parent":20249,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-20888","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/users\/3022"}],"replies":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/comments?post=20888"}],"version-history":[{"count":7,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20888\/revisions"}],"predecessor-version":[{"id":27955,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20888\/revisions\/27955"}],"up":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/20249"}],"wp:attachment":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/media?parent=20888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}