{"id":20983,"date":"2026-04-14T12:22:53","date_gmt":"2026-04-14T11:22:53","guid":{"rendered":"https:\/\/cabd.es\/investigation\/departments\/cell-biology-and-biotechnology\/dr-juan-jimenez-martinez\/"},"modified":"2026-11-03T11:38:45","modified_gmt":"2026-11-03T10:38:45","slug":"dr-juan-jimenez-martinez","status":"publish","type":"page","link":"https:\/\/cabd.es\/en\/investigation\/departments\/multicelular-dynamics\/dr-juan-jimenez-martinez\/","title":{"rendered":"Dr Juan Jim\u00e9nez Mart\u00ednez"},"content":{"rendered":"

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Multicellular Dynamics<\/p>\n

Cell cycle in yeast<\/h1>\n

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Dr Juan Jim\u00e9nez Mart\u00ednez<\/h4>\n

Principal Investigator<\/p>\n

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Summary<\/h2>\n
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Understanding the mechanisms controlling the cell division cycle is an important landmark in modern biology. In higher eukaryotic organisms, cell cycle regulation is a basic event in development where multicellular organisms are generated by controlled cell division and differentiation, and in understanding oncogenesis (abnormal cell divisions).<\/p>\n

Within this topic, our end focus on the characterization of new cell cycle control genes identified by our group using yeast as a model organism. In particular, we study new mechanisms coordinating entry into mitosis and other cellular events such as cell growth and cytokinesis. In addition, we also use the nematode\u00a0C. elegans<\/em>\u00a0to assay the role of the identified genes in processes such as development and aging.<\/p>\n<\/div>\n

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Five relevant publications<\/a><\/h2>\n
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  • Alphey L, Jim\u00e9nez J, White-Cooper H, Dawson I, Nurse P, Glover D (1992) Twine, a cdc25 homologue that function in the male and female germline of Drosophila.\u00a0Cell\u00a0<\/strong>69:977-988.<\/li>\n
  • Thode, G, Ranea, JAG and Jim\u00e9nez J (1996) Search of ancient patterns in protein sequences. J Mol Evol 42: 224-233.<\/li>\n
  • Daga RR and Jim\u00e9nez J (1999) Translational control of the Cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth.\u00a0J. Cell Sci<\/strong>. 112: 3137-3146.<\/li>\n
  • Wood, V., et al. (2002) The genome sequence of the eukaryotic fission yeast, Schizosaccharomyces pombe. Nature 415:871-80.<\/li>\n
  • Daga RR, Lahoz A, Mu\u00f1oz M, Moreno S, Jim\u00e9nez J (2005) Etd1p, a novel protein that links the SIN cascade with cytokinesis.\u00a0EMBO J.<\/strong>\u00a024: 2436-2446.<\/li>\n
  • Fidalgo M, Barrales RR, Ibeas JI and Jim\u00e9nez J (2006). Adaptive evolution by mutations in the FLO11 gene.\u00a0Proc. Natl. Acad. Sci. USA<\/strong>\u00a0103: 11228-11233.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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    Lab members & Collaborators<\/h2>\n
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    Lab members<\/h3>\n

    Principal Investigator:<\/h4>\n

    Prof. Juan Jim\u00e9nez Mart\u00ednez, +34 954349377<\/p>\n

    Former students:<\/h4>\n

    Manuel Fidalgo Merino (Postdoc)
    Aurelia Lahoz Ruano (PhD)
    Ram\u00f3n Ramos Barrales (PhD)
    Fernando Romero Balestra (PhD)
    Rafael Lucena Hern\u00e1ndez (PhD)
    Mar\u00eda Alcaide Gavil\u00e1n (PhD)<\/p>\n

    Laboratory technicians:<\/h4>\n

    Anabel L\u00f3pez Salvador
    Victor M. Carranco Fabre<\/p>\n

    Collaborators<\/h3>\n

    Dr Andr\u00e9s Garz\u00f3n (CABD\/Universidad Pablo de Olavide)
    Dr J.Ignacio Ibeas (CABD\/Universidad Pablo de Olavide)
    Dr Manuel J. Mu\u00f1oz (CABD\/Universidad Pablo de Olavide)<\/p>\n

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