{"id":27388,"date":"2026-06-24T14:17:21","date_gmt":"2026-06-24T13:17:21","guid":{"rendered":"https:\/\/cabd.es\/investigation\/departments\/evolutionary-dynamics\/dr-ildefonso-cases-diaz\/"},"modified":"2026-06-25T14:19:26","modified_gmt":"2026-06-25T13:19:26","slug":"dr-ildefonso-cases-diaz","status":"publish","type":"page","link":"https:\/\/cabd.es\/en\/investigation\/departments\/evolutionary-dynamics\/dr-ildefonso-cases-diaz\/","title":{"rendered":"Dr. Ildefonso Cases D\u00edaz"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_header background_overlay_color=&#8221;rgba(31,31,31,0.56)&#8221; subhead_font_color=&#8221;#bebebe&#8221; admin_label=&#8221;Encabezado de ancho completo&#8221; _builder_version=&#8221;4.27.6&#8243; title_font=&#8221;Montserrat|700|||||||&#8221; title_text_color=&#8221;#ffffff&#8221; title_font_size=&#8221;45px&#8221; 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header_6_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_6_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_6_text_shadow_blur_strength_tablet=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4 style=\"text-align: center;\">\u00a0Dra. Ildefonso Cases D\u00edaz<\/h4>\n<p style=\"text-align: center;\">Associate Investigator<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;3_4&#8243; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;dc6ab383-11a3-454b-8ba1-6554be6042b4&#8243; vertical_offset_tablet=&#8221;0&#8243; horizontal_offset_tablet=&#8221;0&#8243; z_index_tablet=&#8221;0&#8243; text_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; text_text_shadow_vertical_length_tablet=&#8221;0px&#8221; text_text_shadow_blur_strength_tablet=&#8221;1px&#8221; link_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; link_text_shadow_vertical_length_tablet=&#8221;0px&#8221; link_text_shadow_blur_strength_tablet=&#8221;1px&#8221; ul_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; ul_text_shadow_vertical_length_tablet=&#8221;0px&#8221; ul_text_shadow_blur_strength_tablet=&#8221;1px&#8221; ol_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; ol_text_shadow_vertical_length_tablet=&#8221;0px&#8221; ol_text_shadow_blur_strength_tablet=&#8221;1px&#8221; quote_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; quote_text_shadow_vertical_length_tablet=&#8221;0px&#8221; quote_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_2_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_2_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_2_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_3_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_3_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_3_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_4_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_4_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_4_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_5_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_5_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_5_text_shadow_blur_strength_tablet=&#8221;1px&#8221; header_6_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; header_6_text_shadow_vertical_length_tablet=&#8221;0px&#8221; header_6_text_shadow_blur_strength_tablet=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22header_text_color%22%93}&#8221;]<\/p>\n<h2 class=\"uk-heading-divider uk-margin-medium-bottom\">Summary<\/h2>\n<hr \/>\n<div class=\"uk-section-default uk-section uk-padding-remove-top\">\n<div class=\"uk-container uk-container-small\">\n<div class=\"tm-grid-expand uk-child-width-1-1 uk-grid-margin uk-grid uk-grid-stack\">\n<div class=\"uk-first-column\">\n<div class=\"uk-panel uk-margin-remove-first-child uk-margin\">\n<div class=\"el-content uk-panel uk-margin-top\">\n<h5>\u00a0<\/h5>\n<p>Our research focuses on the development and application of artificial intelligence methods to build computational representations of biological entities, including proteins, genes, regulatory regions, cells, and organisms. These representations transform complex biological objects into numerical spaces where they can be compared, organized, and analyzed using mathematical and computational approaches.<\/p>\n<p>A central goal of our work is to understand what biological information is encoded within these representations. In particular, we investigate how properties such as molecular function, evolutionary relationships, biological diversity, and the organization of cellular systems are embedded in these representation spaces, enabling the exploration of biological principles that are not readily apparent from the original data.<\/p>\n<p>Another major area of research involves the development of predictive tools based on these representations. These approaches enable the transfer of knowledge between related proteins, genes, or cells, overcoming some of the limitations of traditional methods that rely exclusively on sequence similarity or homology.<\/p>\n<p>Finally, these representations are used as tools to address fundamental questions in evolutionary and functional biology. These include the study of evolutionary convergence, the emergence of novel biological functions, the organization of protein functional landscapes, and the identification of large-scale evolutionary patterns. The ultimate goal is to use artificial intelligence not only as a predictive tool, but also as a framework for understanding how biological information is organized and evolves.<\/p>\n<div>\u00a0<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><a href=\"https:\/\/cabd.es\/wp-content\/uploads\/2026\/06\/web.png\"><img decoding=\"async\" class=\"wp-image-27383 alignnone size-full lazyload\" style=\"--smush-placeholder-width: 797px; --smush-placeholder-aspect-ratio: 797\/437;display: block; margin-left: auto; margin-right: auto;\" data-src=\"https:\/\/cabd.es\/wp-content\/uploads\/2026\/06\/web.png\" alt=\"\" width=\"797\" height=\"437\" data-srcset=\"https:\/\/cabd.es\/wp-content\/uploads\/2026\/06\/web.png 797w, https:\/\/cabd.es\/wp-content\/uploads\/2026\/06\/web-480x263.png 480w\" data-sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 797px, 100vw\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/a><\/p>\n<p>[\/et_pb_text][et_pb_divider show_divider=&#8221;off&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;d057b755-ffa8-4fcd-923c-c94b7c9a9123&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22color%22%93}&#8221;]<br \/>\n[\/et_pb_divider][et_pb_text admin_label=&#8221;Texto&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;dc6ab383-11a3-454b-8ba1-6554be6042b4&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"uk-heading-divider uk-margin-medium-bottom\">Relevant publications<\/h2>\n<hr \/>\n<div class=\"uk-section-default uk-section uk-padding-remove-top\">\u00a0<\/div>\n<div class=\"uk-section-default uk-section uk-padding-remove-top\">\n<div class=\"uk-container uk-container-small\">\n<div class=\"tm-grid-expand uk-child-width-1-1 uk-grid-margin uk-grid uk-grid-stack\">\n<div class=\"uk-first-column\">\n<div class=\"uk-panel uk-margin-remove-first-child uk-margin\">\n<div class=\"el-content uk-panel uk-margin-top\">\n<p>&nbsp;<\/p>\n<ul>\n<li>\n<div>Fern\u00e1ndez R, Valverde S, Bombarely A,\u00a0<b>Cases I<\/b>, Handley SA, Rojas AM. (2026) Rethinking molecular evolution through protein language model embeddings. Trends Genet. \u00a0Jun 15:S0168-9525(26)00141-1. doi: 10.1016\/j.tig.2026.05.014.<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Mart\u00ednez-Redondo,G.I., Perez-Canales F.M., Carbonetto B., Fern\u00e1ndez J.M., Barrios-N\u00fa\u00f1ez I., V\u00e1zquez-Valls M.,\u00a0<b>Cases, I.<\/b>\u00a0, Rojas A.M. and Fern\u00e1ndez R (2025) FANTASIA leverages language models to decode the functional dark proteome across the Animal Tree of Life .\u00a0Commun Biol.14;8(1):1227. doi: 10.1038\/s42003-025-08651-2<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div><b>Cases I.<\/b>,\u00a0Mart\u00ednez-Redondo G.I., Fern\u00e1ndez R. and Rojas AM. (2025) Functional annotation of proteomes using protein language models: a High-throughput implementation of the ProtTrans model.\u00a0Methods in Molecular Biology, 2941:127-137, doi: 10.1007\/978-1-0716-4623-6_8<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Maya-Miles D, Garc\u00eda-Mart\u00ednez J,\u00a0<b>Cases I,<\/b>\u00a0Pasi\u00f3n R, de la Cruz J, P\u00e9rez-Ort\u00edn JE, Mu\u00f1oz-Centeno MC, Ch\u00e1vez S. (2025) Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle.\u00a0PLoS One. 7;20(5):e0317650. doi: 10.1371\/journal.pone.0317650<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Verdugo-Sivianes EM, Espinosa-S\u00e1nchez A,\u00a0<b>Cases I<\/b>, Rojas AM, Otero-Albiol D, Romero L, Blanco JR, Carnero A. (2024) MEG8 as an antagonistic pleiotropic mechanism in breast cancer. Cell Death Discov. \u00a0Dec 20;10(1):509. doi: 10.1038\/s41420-024-02272-0. PMID: 39706842; PMCID: PMC11662018.<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Barrios-N\u00fa\u00f1ez,I., Mart\u00ednez-Redondo,G.I., Medina-Burgos, P., <b>Cases I<\/b>\u00a0*., Fern\u00e1ndez, R.*, Rojas A.M.* (2024) Decoding functional proteome information in model organisms using protein language models.\u00a0NAR Genomics and Bioinformatics, 6, 3, doi:10.1093\/nargab\/lqae078<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Rueda AD, Salvador-Mart\u00ednez I, Sospedra-Arrufat I, Alcaina-Caro A, Fern\u00e1ndez-Mi\u00f1\u00e1n A, Burgos-Ruiz AM,\u00a0<b>Cases I<\/b>, Mohedano A, Tena JJ, Heyn H, Lopez-Rios J, Nusspaumer G.(2024\u00a0) The cellular landscape of the endochondral bone during the transition to extrauterine life. Immunol Cell Biol. Feb;102(2):131-148. doi: 10.1111\/imcb.12718.<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Marl\u00e9taz F, de la Calle-Mustienes E, Acemel RD, Paliou C, Naranjo S, Mart\u00ednez-Garc\u00eda PM,\u00a0<b>Cases I<\/b>, Sleight VA, Hirschberger C, Marcet-Houben M, Navon D, Andrescavage A, Skvortsova K, Duckett PE, Gonz\u00e1lez-Rajal \u00c1, Bogdanovic O, Gibcus JH, Yang L, Gallardo-Fuentes L, Sospedra I, Lopez-Rios J, Darbellay F, Visel A, Dekker J, Shubin N, Gabald\u00f3n T, Nakamura T, Tena JJ, Lupi\u00e1\u00f1ez DG, Rokhsar DS, G\u00f3mez-Skarmeta JL. (2023) The little skate genome and the evolutionary emergence of wing-like fins. Nature. Apr;616(7957):495-503. doi: 10.1038\/s41586-023-05868-1. Epub 2023 Apr 12. PMID: 37046085<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Fragoso-Luna A, Romero-Bueno R, Eibl M, Ayuso C, Mu\u00f1oz-Jim\u00e9nez C, Benes V, <b>Cases I<\/b>,\u00a0Askjaer P. (2023) Expanded FLP toolbox for spatiotemporal protein degradation and transcriptomic profiling in Caenorhabditis elegans.\u00a0Genetics. 223(1):iyac166. doi: 10.1093\/genetics\/iyac166<\/div>\n<div>\u00a0<\/div>\n<\/li>\n<li>\n<div>Leon A, Subirana L, Magre K,\u00a0<b>Cases I,<\/b>\u00a0Tena JJ, Irimia M, Gomez-Skarmeta JL, Escriv\u00e1 H, Bertrand S. (2022) Gene Regulatory Networks of Epidermal and Neural Fate Choice in a Chordate.\u00a0Mol Biol Evol. 39(4):msac055. doi: 10.1093\/molbev\/msac055.<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][et_pb_divider show_divider=&#8221;off&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;d057b755-ffa8-4fcd-923c-c94b7c9a9123&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22color%22%93}&#8221;]<br \/>\n[\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evolutionary Dynamics Bioinformatics and Computational Biology \u00a0Dra. Ildefonso Cases D\u00edaz Associate Investigator &nbsp;Summary \u00a0 Our research focuses on the development and application of artificial intelligence methods to build computational representations [&hellip;]<\/p>\n","protected":false},"author":3060,"featured_media":0,"parent":21570,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-27388","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/27388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/users\/3060"}],"replies":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/comments?post=27388"}],"version-history":[{"count":6,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/27388\/revisions"}],"predecessor-version":[{"id":27423,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/27388\/revisions\/27423"}],"up":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/pages\/21570"}],"wp:attachment":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/media?parent=27388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}