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Scientific advances<\/p>\n
[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.6″ vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ hover_enabled=”0″ z_index_tablet=”0″ text_text_shadow_horizontal_length_tablet=”0px” text_text_shadow_vertical_length_tablet=”0px” text_text_shadow_blur_strength_tablet=”1px” link_text_shadow_horizontal_length_tablet=”0px” link_text_shadow_vertical_length_tablet=”0px” link_text_shadow_blur_strength_tablet=”1px” ul_text_shadow_horizontal_length_tablet=”0px” ul_text_shadow_vertical_length_tablet=”0px” ul_text_shadow_blur_strength_tablet=”1px” ol_text_shadow_horizontal_length_tablet=”0px” ol_text_shadow_vertical_length_tablet=”0px” ol_text_shadow_blur_strength_tablet=”1px” quote_text_shadow_horizontal_length_tablet=”0px” quote_text_shadow_vertical_length_tablet=”0px” quote_text_shadow_blur_strength_tablet=”1px” header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength_tablet=”1px” header_2_text_shadow_horizontal_length_tablet=”0px” header_2_text_shadow_vertical_length_tablet=”0px” header_2_text_shadow_blur_strength_tablet=”1px” header_3_text_shadow_horizontal_length_tablet=”0px” header_3_text_shadow_vertical_length_tablet=”0px” header_3_text_shadow_blur_strength_tablet=”1px” header_4_text_shadow_horizontal_length_tablet=”0px” header_4_text_shadow_vertical_length_tablet=”0px” header_4_text_shadow_blur_strength_tablet=”1px” header_5_text_shadow_horizontal_length_tablet=”0px” header_5_text_shadow_vertical_length_tablet=”0px” header_5_text_shadow_blur_strength_tablet=”1px” header_6_text_shadow_horizontal_length_tablet=”0px” header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” global_colors_info=”{}” _module_preset=”dc6ab383-11a3-454b-8ba1-6554be6042b4″ sticky_enabled=”0″]<\/p>\n
A study co-led by the CABD and IRBio (UB) identifies the essential function of a protein control system in the regeneration of tissues and organs in a type of insect.<\/p>\n
<\/p>\n
The results contribute to the knowledge of the genetic mechanisms involved in regeneration and provide clues to the role of this molecular process in human diseases.<\/p>\n
A study co-led by Fernando Casares, from the Centro Andaluz de Biolog\u00eda del Desarrollo (CABD, CSIC-JA-UPO) and Isabel Almud\u00ed, from the Institut de Recerca de la Biodiversitat (IRBio) of the University of Barcelona, shows the involvement of neddylation, a protein quality control pathway, in tissue regeneration in mayflies (Cloeon dipterum), a type of insect capable of rapid regeneration.
many of its organs. The results, published in the journal Open Biology, open the door to the investigation of this molecular process in the regeneration of organs in vertebrates and in the development of future therapies.
In nature, not all animals have the ability to regenerate damaged or lost organs. In particular, humans have a very limited regenerative capacity compared to other animals. Fernando Casares points out that \u201cunderstanding how some organisms regenerate their organs efficiently will allow us to understand this process at the molecular, cellular and organ level, and opens a window to understand not only why some organisms regenerate well, but also why we regenerate poorly\u201d.
This work contributes to filling this gap in our knowledge of this process by studying regeneration in the ephemeral Cloeon dipterum, a freshwater insect that only emerges from the water once it reaches adulthood. Thus, aquatic juveniles, also called nymphs, have a pair of gills on each of their first seven abdominal segments. These are flat, paddle-like organs that are essential for respiration, osmoregulation (the maintenance of water and salt balance within the body) and, probably, for the detection of chemicals.
Often, however, these gills are shed from the body to make room for new ones that are generated in a time span of five to nine days. \u201cThese new gills not only regenerate, but during the process they grow at a faster rate than during normal development,\u201d says Casares. Experiments carried out by the research team show that this rapid regeneration does not seem to be due to the growth of a specialized region (which is formed in many regeneration processes and is called blastema), but is produced by a uniform increase in cell proliferation throughout the gill.<\/p>\n
In this work, in which Carlos A. Martin-Blanco, doctoral researcher at the CABD and the University of Barcelona, has played an essential role, a protein quality control pathway, called neddylation, has been identified as fundamental for insects to regenerate their appendages. Defective proteins, or those that should be eliminated if they are no longer needed for cell function, are discarded through a specialized machinery called the proteasome. \u201cHowever, this machinery is subject to regulation and it is precisely the chemical addition of the Nedd8 protein to some of the proteasome components that activates this machinery,\u201d explains Mart\u00edn-Blanco.<\/p>\n
In addition to its role in regeneration, Neddylation is involved in the regulation of metabolism, immune system function and tumorigenesis. Interestingly, the researchers point out that tumor development is related to the overexpression of this molecular process. In fact, there are drugs that block this mechanism and that are used as antitumor drugs.
Isabel Almud\u00ed comments that this work brings new discoveries, but also new questions: \u201cCould it be that organs in the process of regeneration and tumors share some molecular mechanisms?<\/p>\n
A door to future research<\/strong><\/p>\n The published work identifies other mechanisms involved in regeneration, such as those related to the activin organ growth control pathway, or the Lin28 protein, which regulates the stability of certain RNAs. It also shows, through functional assays in another insect, the vinegar fly Drosophila, that these mechanisms are conserved within insects, opening doors to investigate whether these processes are also important in organ regeneration in vertebrates. Carlos A. Mart\u00edn-Blanco, Pablo Navarro, Jos\u00e9 Esteban-Collado, Florenci Serras, Isabel Almud\u00ed and Fernando Casares.\u00a0Gill regeneration in the mayfly Cloeon uncovers new molecular pathways in insect regeneration<\/b>.\u00a0Open Biology<\/i>.\u00a0doi.org\/10.1098\/rsob.240118 [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Scientific advancesKey molecular mechanism for tissue regeneration discovered in insects A study co-led by the CABD and IRBio (UB) identifies the essential function of a protein control system in the […]<\/p>\n","protected":false},"author":2997,"featured_media":19007,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[184],"tags":[],"class_list":["post-21174","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-advances"],"_links":{"self":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/posts\/21174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/users\/2997"}],"replies":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/comments?post=21174"}],"version-history":[{"count":8,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/posts\/21174\/revisions"}],"predecessor-version":[{"id":26937,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/posts\/21174\/revisions\/26937"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/media\/19007"}],"wp:attachment":[{"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/media?parent=21174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/categories?post=21174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cabd.es\/en\/wp-json\/wp\/v2\/tags?post=21174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
The next challenge for researchers will be to try to stimulate these processes in organs that regenerate poorly and to analyze whether their regenerative capacities are enhanced. This discovery could have implications in fields such as biomedicine, since regenerative mechanisms in other animals are a source of inspiration for future therapies in humans.<\/p>\n
<\/a> This press release was written in collaboration with the units of comunication from CSIC, CSIC Andaluc\u00eda and IRBio (UB).<\/strong><\/p>\n