Multicellular Dynamics

Cell cycle in yeast

Dr Juan Jiménez Martínez

Principal Investigator

Summary


 

Understanding the mechanisms controlling the cell division cycle is an important landmark in modern biology. In higher eukaryotic organisms, cell cycle regulation is a basic event in development where multicellular organisms are generated by controlled cell division and differentiation, and in understanding oncogenesis (abnormal cell divisions).

Within this topic, our end focus on the characterization of new cell cycle control genes identified by our group using yeast as a model organism. In particular, we study new mechanisms coordinating entry into mitosis and other cellular events such as cell growth and cytokinesis. In addition, we also use the nematode C. elegans to assay the role of the identified genes in processes such as development and aging.

Five relevant publications


  • Alphey L, Jiménez J, White-Cooper H, Dawson I, Nurse P, Glover D (1992) Twine, a cdc25 homologue that function in the male and female germline of Drosophila. Cell 69:977-988.
  • Thode, G, Ranea, JAG and Jiménez J (1996) Search of ancient patterns in protein sequences. J Mol Evol 42: 224-233.
  • Daga RR and Jiménez J (1999) Translational control of the Cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth. J. Cell Sci. 112: 3137-3146.
  • Wood, V., et al. (2002) The genome sequence of the eukaryotic fission yeast, Schizosaccharomyces pombe. Nature 415:871-80.
  • Daga RR, Lahoz A, Muñoz M, Moreno S, Jiménez J (2005) Etd1p, a novel protein that links the SIN cascade with cytokinesis. EMBO J. 24: 2436-2446.
  • Fidalgo M, Barrales RR, Ibeas JI and Jiménez J (2006). Adaptive evolution by mutations in the FLO11 gene. Proc. Natl. Acad. Sci. USA 103: 11228-11233.

Lab members & Collaborators


Lab members

Principal Investigator:

Prof. Juan Jiménez Martínez, +34 954349377

Former students:

Manuel Fidalgo Merino (Postdoc)
Aurelia Lahoz Ruano (PhD)
Ramón Ramos Barrales (PhD)
Fernando Romero Balestra (PhD)
Rafael Lucena Hernández (PhD)
María Alcaide Gavilán (PhD)

Laboratory technicians:

Anabel López Salvador
Victor M. Carranco Fabre

Collaborators

Dr Andrés Garzón (CABD/Universidad Pablo de Olavide)
Dr J.Ignacio Ibeas (CABD/Universidad Pablo de Olavide)
Dr Manuel J. Muñoz (CABD/Universidad Pablo de Olavide)