Multicelular Dynamics

Molecular and cellular mechanisms regulating epithelia morphogenesis and homeostasis

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  • Valencia-Expósito, A., Gómez-Lamarca, M.J., Widmann, T. and Martín-Bermudo, M.D. (2022).
    Integrins cooperate with the EGFR/Ras pathway to promote epithelia survival and architecture in development and oncogenesis. Front. Cell Dev Biol., 13 June 2022.
    https://doi.org/10.3389/fcell.2022.892691

  • Hernández-del-Valle, M., Valencia-Expósito, A., Gorfinkel, N., Martín-Bermudo, M. D. and Míguez Gómez, D. (2022).
    Analysis of the actomyosin oscillatory dynamics using a coarse-grained model. Frontiers in Physics.
    https://doi.org/10.3389/fphy.2022.881384

  • KluBmann-Fricke, B.J.1,3, Martín-Bermudo, M.D.2,* and Llimargas, M.1,*. (2022).
    The Basement Membrane controls size and integrity of the Drosophila tracheal tubes. Cell Reports, 39.
    https://doi.org/10.1016/j.celrep.2022.110734

  • Hernández-del-Valle, M., Valencia-Expósito, A., López-Izquierdo, A., Casanova-Ferrer, P., Tarazona, P., Martín-Bermudo, M. D., and Míguez Gómez, D. (2022).
    A coarse-grained approach to model the dynamics of the actomyosin cortex. BMCB.
    https://doi.org/10.1186/s12915-022-01279-2

  • Pérez Moreno, J., Santa-Cruz Mateos C., Martín-Bermudo, M. D., and Estrada, B. (2021).
    LanB1 cooperates with Kon-tiki during embryonic muscle migration in Drosophila. Frontiers in Cell and Dev. Biol. 9:749723.
    https://doi.org/10.3389/fcell.2021.749723

  • Soler Beatty, J., Molnar, C., Luque, C.M., de Celis J.F. and Martin-Bermudo, M.D.* (2021).
    EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis. PLoS Genetics. Aug.
    https://doi.org/10.1371/journal.pgen.1009738

  • Braun A.L, Meghini F., Villa-Fombuena G., Guermont M., Fernandez-Martinez E., Qian Z., Martín- Bermudo M.D., González-Reyes A., Glover D. M., and Kimata Y. (2021).
    The careful control of Polo Kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes during Drosophila oogenesis. Open Biol. Jun; 11(6):200371.
    https://doi.org/10.1098/rsob.200371

  • Palacios, I.*, Vicente-Crespo, M.* and Martin-Bermudo, M.D.* (2020).
    The humble fruit fly is helping the African science community to thrive. Nature Rev. Mol. Cell Biol.
    https://doi.org/10.1038/s41580-020-00283-0

  • Santa-Cruz Mateos, C., Valencia-Expósito, A., Palacios, I.M. and Maria D. Martin-Bermudo (2020).
    Integrins regulate epithelia cell shape by controlling the architecture and mechanical properties of basal actomyosin networks. PLoS Genetics, 16 (6).
    https://doi.org/10.1371/journal.pgen.1008717

  • J. Dai, B. Estrada, Sofie Jacobs, B. J. Sánchez-Sánchez, J. Tang, M. Ma, P. Magadán-Corpas, José C. Pastor-Pareja* and María D. Martín-Bermudo* (2018).
    Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly. PLoS Genetics, 14 (9).
    https://doi.org/10.1371/journal.pgen.1007483

  • P. Gómez-Gálvez, P. Vicente-Munuera, A. Tagua, C. Forja, A. M. Castro, M. Letrán, A. Valencia Expósito, C. Grima, M. Bermúdez-Gallardo, Ó. Serrano-Pérez-Higueras, F. Cavodeassi, S. Sotillos, María D. Martín-Bermudo, A. Márquez, J. Buceta and Luis M. Escudero (2018).
    Scutoids are a geometrical solution to threedimensional packing of epithelia. Nature Communications, 9, 2960.
    https://doi.org/10.1016/10.1038/s41467-018-05376-1

  • B. J. Sánchez-Sánchez, Urbano, J.M., Comber, K., Dragu, A., Wood, W., Stramer, B. and M. D. Martín-Bermudo (2017).
    Drosophila embryonic hemocytes produce laminins to strengthen migratory response. Cell Reports, 21,1461-1470.
    https://doi.org/10.1016/j.celrep.2017.10.047

  • Martín-Bermudo, M. D.*, Gebel, L. and Palacios, I.M.* (2017).
    (*Co-corresponding authors). DrosAfrica: Building an African biomedical research community using Drosophila. Seminars in Cell & Developmental Biology.
    http://dx.doi.org/10.1016/j.semcdb.2017.08.044

  • M. C. Díaz de la Loza, A. Díaz-Torres, F. Zurita, E. Moeendarbary, K. Franze, M. D. Martín-Bermudo* and A.González-Reyes* (2017).
    (*Co-corresponding authors). Laminin levels regulate tissue migration and Anterior-Posterior polarity during egg morphogenesis in Drosophila. Cell Reports, 20, 211-233.
    http://dx.doi.org/10.1016/j.celrep.2017.06.031

  • B. F. Ng, G. K Selvaraj, C. Santa-Cruz Mateos, I. Grosheva, I. Alvarez-Garcia, M. D. Martin-Bermudo, and I. M Palacios (2016).
    Alpha-spectrin is essential for septate junction formation and columnarization, but not for proliferation control, in the follicular epithelium. Development, 143, 1388-1399.
    https://doi.org/10.1242/dev.130070

  • Valencia-Expósito, A., Grosheva, I., Míguez, D.G., González-Reyes, A. and Martín-Bermudo, M. D. (2016).
    Myosin Light Chain Phosphatase regulates basal actomyosin oscillations during morphogenesis. Nature Communications, 7, 10798.
    https://doi.org/10.1038/ncomms10746

  • J. R. Pearson, F. Zurita, L. Tomás-Gallardo, A. Díaz-Torres, M. C. Díaz de la Loza, K. Franze, M. D. Martín-Bermudo and A. González-Reyes. (2016).
    timp-mediated ECM regulation is required for stem cell niche organization and cyst production in the Drosophila ovary. PLoS Genetics, 1005763.
    https://doi.org/10.1371/journal.pgen.1005763

  • Martín-Bermudo, M. D., Pierre-Luc Bardet, Yohanns Bellaicheand and Malartre, M. (2015).
    The Vav oncogene antagonizes EGFR signaling and regulates adherens junction dynamics during Drosophila eye development. Development, 142: 1492-1501.
    https://doi.org/10.1242/dev.110585

  • Gómez-Lamarca, M.J., Cobreros Reguera, L., Ibáñez-Jiménez, B.,Palacios, I.M. and M. D. Martín-Bermudo (2014).
    Integrins regulate epithelial cell differentiation by modulating Notch activity. J. Cell Science, 127: 4667-4678.
    https://doi.org/10.1242/jcs.153122

  • Pérez Moreno, J., Bischoff, M., M. D. Martín-Bermudo and Estrada, B. (2014).
    The transmembrane proteoglycan Perdido is essential for in vivo myofibrillogenesis and proper sarcomeric structure. J. Cell Science, 127: 3162-3173.
    https://doi.org/10.1242/10.1242/jcs.150425

  • K. Comber, S. Huelsmann, I. Evans, B. J. Sánchez-Sánchez, A. Chalmers, R. Reuter, W. Wood and M. D. Martín-Bermudo (2013).
    A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration. J. Cell Science, 126: 3475-3484.
    https://doi.org/10.1242/jcs.129700

  • C. H. Fernández-Espartero, D. Ramel, M. Farago, M. Malartre, C. M Luque, S. Limanovich, S. Katzav, G. Emery and Martín-Bermudo, M. D. (2013).
    The GEF Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation. J. Cell Science, 126:2285-2293.
    https://doi.org/10.1242/jcs.124438

  • J.M. Urbano, Domínguez Jiménez, P., Estrada, B. and M.D. Martín-Bermudo (2011).
    PS integrins and Laminins: Key Regulators of cell migration during Drosophila embryogenesis. PLoS One 6 (9); e23893.
    https://doi.org/10.1371/journal.pone.0023893

  • Cobreros Reguera, L, Fernández-Miñán, A., Fernández-Espartero, C.H., López-Schier, H., González-Reyes, A* and Martín-Bermudo, M.D. * (2010).
    The Ste-20 like kinase misshapen regulates the invasive behaviour of ovarian epithelial cells in Drosophila. (*Co-corresponding authors). EMBO Reports, 11:943-949.

  • Malartre, M., Derya, A., Fernández-Amador, F. and Martín-Bermudo, M. D. (2010).
    The guanine exchange factor vav controls axon growth and guidance during Drosophila development. J Neuroscience, 30:2257-2267.
    https://doi.org/10.1523/jneurosci.1820-09.2010

  • Hidalgo, A. and Martín-Bermudo, M.D. (2009).
    1st joint meeting of the British and Spanish Developmental Biology Societies. International Journal of Developmental Biology, 53: 443-446.

  • J.M. Urbano, C.N. Torgler, C.Molnar, U.Tepass, A.López-Varea, N.H. Brown, J F. de Celis and M.D. Martín-Bermudo (2009).
    Drosophila Laminins Act as Key Regulators of Basement Membrane Assembly and Morphogenesis. Development, 136: 4165-4176.

  • Martinez-Morales, JR.., Rembold, M., Greger, K., Simpson, J.C., Brown, K. E., Quiring, R., Pepperkok, R., Martin-Bermudo, M. D., Himmelbauer, H. and Wittbrodt, J. (2009).
    ojoplano-mediated basal constriction is essential for optic cup morphogenesis. Development, 136: 2165-2175.

  • Cobreros Reguera, L, Fernández-Miñán, A., Luque, C.M., González-Reyes, A and Martín-Bermudo, M.D. (2008).
    A role for the chaperone HSP70 in the regulation of border cell migration in the Drosophila ovary. Mechanisms of Development, 125:1048-1058.

  • Fernández-Miñán, A., Cobreros Reguera, L., González-Reyes, A and Martín-Bermudo, M.D. (2008).
    Integrins contribute to the establishment and maintenance of cell polarity in the follicular epithelium of the Drosophila ovary. International Journal of Developmental Biology, 52:925-932.

  • Fernández-Miñán, A., Martín-Bermudo, M. D.* and González-Reyes, A.*(2007).
    Integrin signalling regulates spindle orientation in the Drosophila ovary to maintain the monolayer follicular epithelium in the follicular epithelium of the Drosophila ovary (*Co-corresponding authors). Current Biology, 17: 683-688.

  • Domínguez Jiménez, P., Brown, N.H. and Martín-Bermudo, M.D. (2007).
    Integrins-ECM interactions regulate the changes in cell shape driving the morphogenesis of the Drosophila wing epithelium. J.Cell Science, 120: 1050-1060.

  • Tanentzapf, G, Martín-Bermudo, M.D., Hicks, M.S. and Brown, N.H. (2006).
    Múltiple factors contribute to integrin-talin interactions in vivo. J.Cell Science, 119:1632-1644.

  • Couceiro,J., Martín-Bermudo, M.D. and Bustelo, X.(2005).
    Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family. Exp. Cell Research, 308:364-380.

  • Martín-Bermudo, M.D. (2002).
    Competing for Dpp: a fight for survival. The Elso Gazzete, 10, 1-3.

  • Boube, M., Martín-Bermudo, M.D., Brown, N. and Casanova, J. (2001).
    Specific tracheal migration is mediated by complementary expression of cell surface proteins. Genes and Development, 15, 1554-1562.

  • Brown, N., Gregory, S.L. and Martín-Bermudo, M.D. (2000).
    Integrins as mediators of morphogenesis in Drosophila. Developmental Biology, 223, 1-16.

  • Martín-Bermudo, M.D., and Brown, N. (2000).
    Localized assembly of ECM integrin ligands requires cell-cell contact. J. Cell Science, 113, 3715-3723.

  • Martín-Bermudo, M.D. (2000).
    Integrins regulate Efgr activity to mediate cell differentiation in the Drosophila embryo. Development 127, 2607-2615.