Organismal Dynamics

Coenzyme Q synthesis in Saccharomyces cerevisae and its implication in the mitochondrial health. lifespan and ageing

Dr Carlos Santos Ocaña

Principal Investigator

Summary

In progress…

Most relevant publications

Doimo, M., Trevisson, E., Airik, R., Bergdoll, M., Santos-Ocaña, C., Hildebrandt, F., Navas, P., Pierrel, F., and Salviati, L. (2014). Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency. Biochim. Biophys. Acta 1842, 1–6.
González-Mariscal, I., García-Testón, E., Padilla, S., Martín-Montalvo, A., Pomares-Viciana, T., Vazquez-Fonseca, L., Gandolfo-Domínguez, P., and Santos-Ocaña, C. (2014). Regulation of coenzyme Q biosynthesis in yeast: A new complex in the block. IUBMB Life n/a–n/a.
Heeringa, S.F., Chernin, G., Chaki, M., Zhou, W., Sloan, A.J., Ji, Z., Xie, L.X., Salviati, L., Hurd, T.W., Santos Ocaña, C., Vega-Warner, V., et al. (2011). COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121, 2013–2024.
Jimenez-Hidalgo, M., Santos-Ocaña, C., Padilla, S., Villalba, J.M., López-Lluch, G., Martín-Montalvo, A., Minor, R.K., Sinclair, D.A., de Cabo, R., Navas, P., et al. (2009). NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8, 140–151.
Martin-Montalvo, A., Gonzalez-Mariscal, I., Padilla, S., Ballesteros, M., Brautigan, D.L., Navas, P.P., and Santos-Ocana, C. (2011). Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem. J. 114, 107–114.
Martin-Montalvo, A., Gonzalez-Mariscal, I., Pomares-Viciana, T., Padilla-Lopez, S., Ballesteros, M., Vazquez-Fonseca, L., Gandolfo, P., Brautigan, D.L., Navas, P., Santos-Ocana, C. (2013). The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast. J. Biol. Chem. 288, 28126–28137.
Padilla, S., Tran, U.C., Jiménez-Hidalgo, M., López-Martín, J.M., Martín-Montalvo, a, Clarke, C.F., Navas, P., and Santos-Ocaña, C. (2009). Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cell. Mol. Life Sci. 66, 173–186.
Padilla-López, S., Jiménez-Hidalgo, M., Martín-Montalvo, A., Clarke, C.F., Navas, P., and Santos-Ocaña, C., (2009). Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1788, 1238–1248.
Salviati, L., Trevisson, E., Rodriguez Hernandez, M.A., Casarin, A., Pertegato, V., Doimo, M., Cassina, M., Agosto, C., Desbats, M.A., Sartori, G., Santos-Ocaña, C., et al. (2012). Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. J. Med. Genet. 49, 187–191.

Lab members & collaborators

Lab member

Head of the goup

Dr Carlos Santos Ocaña, +34 954 349 093, csanoca@upo.es orcid.org/0000-0002-2379-796X

PhD Students

Elena García-Testón Páez

Collaborators

Dr. Rafael Carlos de Cabo Moreno (NIA-NIH Baltimore)
Dr. David Brautigan (University of Virginia, Charlottesville)
Dr. Catherine F. Clarke (University of California Los Angeles)
Dr. José Manuel Villalba Montoro (Universidad de Córdoba)
Dr. Leonardo Salviati (Università di Padova)
Dr. Sergio Padilla López (Sanford Health Research Center, Sioux Falls, SD)
Dr. Rafael Artuch (Hospital San Joan de Deu, Barcelona)
Dra. Sandra Jackson (Tech University Hospìtal, Dresden)